Antimicrobial resistance of 160 clinical isolates of Haemophilus influenzae from children

Objective: To investigate the resistance a nd p revalence of beta-lactamase in Haemophilus influenzae isolated from childre n patients with infection for the reasonable use of antibiotics. Meth o ds: Kirby-Bauer disc method was used for susceptibility tests of the isolates. Nitrocefin was used to detect beta-lactamase of the isolates. Results: The resistance rates of H. influenzae isolates to amp i cillin, TMP-SMZ, tetracycline, chloramphenicol, erythromycin, cefaclor, and cip rofloxacin were 15.6%, 53.8%, 34.4%, 14.4%, 2.5%, 1.3% and 0.6% respectively . Beta-lactamase was positive in 16.3% of the strains tested. No beta-lactamas e-negative ampicillin-resistant (BLNAR) H. influenzae was found. Conclusions: The resistance of H. influenzae isolated from chil d ren patients is high with a number of multi-resistance strains in this area. Ce ftriaxone, ciprofloxacin and azithromycin have good antibacterial activity again st this organism. [