Indacaterol solid dispersion and pharmaceutical composition containing same

2014 
The invention provides an indacaterol solid dispersion and a pharmaceutical composition containing the same. The indacaterol solid dispersion comprises (1) indacaterol, (2) one or more of crosslinked polyvinylpyrrolidone, lactose, polyethylene glycol and microcrystalline cellulose; (3) sodium dodecyl sulfate. The pharmaceutical composition comprises the indacaterol solid dispersion and a pharmaceutically acceptable carrier. By making the indacaterol into a solid dispersion, the drug solubility is improved, the dissolution speed of the drug is increased, and the dissolution rate of the pharmaceutical composition containing the solid dispersion is greatly improved in a dissolving medium; moreover, in a grinding process, the premixing of the drug and partial accessories is realized, and the problems in the content uniformity of a small-dose preparation are remarkably reduced.
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