Chemoprevention as a way to control epigenetic changes (Analytical review of the literature)

Epigenetic alterations have been identified as promising new targets for cancer prevention strategies as they occur early during carcinogenesis. Therapy is mainly focused on reversion of DNA methylation by inhibiting DNA-methyltransferases and low level of acetylated histones by inhibiting histone deacetylases. DIM and epigallocatechin-3-gallate (EGCG) substances are believed to be an anticancer agent in part through its regulation of epigenetic processes. These agents demonstrate efficacy in cancer chemopreventive action and have potential to be used to current cancer therapies.