폐경후 증후군 환자에서 Estradiol Patch 치료의 임상 효과 -제 1 보-

We evaluated clinical efficacy and acceptability of transdermal estradiol patch treatment (beta estro, 1 mg/patch) in 30 patients with hot flushes and/or postmenopausal syndrome. 26 of 29 patients with hot flushes and 1 patient with postmenopausal syndrome were found to experience the improvement of symptoms. 1 of 3 patients who did not experience clinical improvement with patch treatment experienced the improvement of urinary symptoms and headaches. Among 3 of 26 patients who experienced improvement in hot flushes, 1 patient sufferes aggravation of headache and 2 patients complained generalized myalgia and dysphoria during treatment. 1 patient whose symptoms had not improved was the one who had the history of skin allergy against plasters and suffered the severe irritation symptoms at the sites of patch application and stopped the patch trement at 10th day of trial. The other 29 did not complain any side effects other than mild skin hyperemia at the site of plaster contact. 25 patients agreed that estradoil (beta estro 1 mg/patch) treatment for two weeks were "effective: in the amenlioration of their postmenpausal symptoms. The above findings showed that the trasdermal estradiol patch treatment improved severity scroes of hot flushes and symptoms of postmenopausal syndrome. Any significant side effect to stop the treament was not observed for 2 weeks of treament and the ratio (83%) of the subjective "effective" group with transdermal estradiol therapy suggessted that this modality might be an alternative of estrogen delivery for longterm treatment in patients with hot flushes and postmenopausal syndromes. (J Kor Soc Endocrinol 5: 131~140, 1990)