Nutritional Status and Lipid Profile in HIV-Infected Adults.
2015
In the last decades, there have been many reports of HIV infection and abnormalities in
lipid metabolism and cardiovascular disease (CVD). This study aims at describing the nutritional
status of HIV-infected adults and its relation to lipid profile through traditional [total cholesterol
(TC), HDL cholesterol (HDL), triglycerides (TG), non-HDL cholesterol and LDL cholesterol (LDL)]
and other parameters [Apolipoprotein B (ApoB), fibrinogen, and high sensitive-C-reactive protein
(hs-CRP)].
A cross-sectional descriptive study was performed. Body mass index (BMI) was calculated and references were taken
from WHO. TC, HDL, TG and glucose were determined and non-HDL cholesterol and LDL were calculated. ApoB and
fibrinogen were determined by quantitative radial immunodiffusion on agar plates (Diffuplate,Biocientifica SA,Argentina)
and hs-CRP by immunoturbidimetric test. Qualitative variables were compared with the Chi-square test or Fisher's exact
test. Quantitative variables were compared applying parametrics or nonparametric tests. Pearson test for correlations.
Software SPSS 17.0. 97 patients were analyzed: 69.1% were men. 80% were on antiretroviral treatment. Average (SD)
BMI was 24.3 (4.1) kg/m 2 . 29.4% were overweight and 5.9% obese. Patients with a BMI ≥25.0 kg/m 2 presented
significantly higher levels of TG, ApoB and glycemia than well-nourished people [246.1(169.0) vs. 142.9(78.4)
mg/dL;p=0.029, 198.6(69.3) vs. 126.4(50.6) mg/dL;p=0.01 and 100 (3.2) vs. 90.2 (6.9) mg/dL;p=0.008 resp.] and a
significantly decreased HDL [37.2(1.5) vs. 49.8(10.4) mg/dL;p<0.01]. No statistically significant correlation was found
between ApoB and non-HDL (p=0,063). There was no evidence that there is a direct relation between Apo B and the other
lipid parameters. The potential increase in CVD in this group of patients, would be related to the higher levels of TG,
ApoB and overweight/obesity. Nutritional education is needed to promote a healthy weight to warn against the risk of
cardiovascular disease.
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