Role of long non-coding RNA in tumor drug resistance development

With the continuous research and elucidation of the role and species of long non-coding RNAs (lncRNAs), the relationship between lncRNAs and cancer resistance has been paid more and more attention by researchers. Studies find that lncRNAs are involved in tumor drug resistance by altering DNA repair and cell cycle, drug delivery system, drug metabolism, cell apoptosis and epithelial interstitial transformation. lncRNAs are expected to be a new biological marker, which provids a new way to diagnose, treat and evaluate the prognosis of cancer. Key words: RNA; Neoplasms; Drug resistance