Synthesis of azinylthioureas and their heterocyclization using α-chloroacetoacetic ester

Treatment of aminopyrimidines with a mixture of PhCOCl and NH4SCN and subsequent debenzoylation of the N-benzoyl-N′-(4,6-substituted pyrimidin-2-yl)thioureas obtained gave pyrimidinyl-2-thioureas. The heterocyclization of the azinyl-2-thioureas with α-chloroacetoacetic ester gave ethyl 2-(4,6-substituted azin-2-yl)aminothiazole-5-carboxylates.