Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats

Eriko Negishi,Noboru Fukuda,Tomoyasu Otsuki,Mayumi Katakawa,Kazutoshi Komatsu,Lan Chen,Sho Tanaka,Hiroki Kobayashi,Yoshinari Hatanaka,Takahiro Ueno,Morito Endo,Tomoji Mashimo,Akira Nishiyama,Masanaori Abe

Involvement of complement 3 in the salt-sensitive hypertension by activation of renal renin-angiotensin system in spontaneously hypertensive rats

2018

Eriko Negishi
Noboru Fukuda
Tomoyasu Otsuki
Mayumi Katakawa
Kazutoshi Komatsu
Lan Chen
Sho Tanaka
Hiroki Kobayashi
Yoshinari Hatanaka
Takahiro Ueno
Morito Endo
Tomoji Mashimo
Akira Nishiyama
Masanaori Abe

We previously showed that complement 3 (C3) is highly expressed in mesenchymal tissues in spontaneously hypertensive rats (SHR). We targeted C3 gene by zinc-finger nuclease (ZFN) gene-editing techn...

Keywords:

Diabetes mellitus
Biochemistry
Zinc finger nuclease
Fibrosis
Renin–angiotensin system
Endocrinology
Biology
Mesenchymal stem cell
Gene
Nuclease
Internal medicine
Spontaneously hypertensive rat
Liver X receptor
Blood pressure
Kidney

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