Cytotoxic triterpenoids from Lysimachia parvifolia.

Abstract Five new oleanane-type triterpenoids, including two aglycones, 13β-28-epoxy-3β,22α,23-trihydroxyolean-16-one ( 1 ) and 13β-28-epoxy-22α,23-dihydroxyolean-3,16-dione ( 2 ), and three glycosides, anagalligenone-3- O -α- l -arabinopyranoside ( 3 ), anagalligenone-3- O -[β- d -glucopyranosyl(1 → 4)-α- l -arabinopyranoside] ( 4 ) and anagalligenone-3- O -[β- d -xylopyranosyl(1 → 2)-β- d -glucopyranosyl(1 → 4)-α- l -arabinopyranoside] ( 5 ), were isolated from the aerial parts of Lysimachia parvifolia , together with three known oleanane-type triterpenoid glycosides ( 6 – 8 ). The structures of the new compounds were subsequently elucidated by spectroscopic analysis and their cytotoxicities evaluated against six human cancer cell lines. Compounds 5 – 8 exhibited significant cytotoxicities against all the cell lines tested, with IC 50 values lower than 10 μM. The possible mechanism of action of compound 6 was also studied.