High-dose therapy with autologous stem cell rescue in patients with breast cancer at high risk for relapse

824 Background: One of the potential drawbacks of high-dose chemotherapy (HD-CT) in breast cancer is transplant related mortality and long term complications associated with conditioning regimens. Hence, the optimum conditioning regimen is yet to be defined. We evaluated the efficacy and safety of combination thiotepa, mitoxantrone and carboplatin (TMJ) as a standard conditioning regimen. Methods: Hundred seventeen patients with stage II or IIIA with four or more positive lymph nodes were consecutively enrolled in this study. Following initial staging patients received three cycles of modified CAF chemotherapy (cyclophosphamide 500 mg/m2 day 1, Doxorubicin 50 mg/m2 day 1 and 5-FU 600 mg/m2 on day 1 and day 8). Peripheral blood stem cell collection was performed following mobilization with cyclophosphamide 2gm/m2 on day 1 and 2 (total dose of 4gms/m2), etoposide 150mg/m2 on days 1, 2 and 3 (total dose of 450mg/m2) and cytokines. Following stem cell collection patients received HD-CT with thiotepa 250mg/m2 ...