Abstract 20726: Study on the Effect of Different Exercise Intensity on Cardiac Function of Rats With Acute Myocardial Infarction and Differential Expression of Circulating MiRNAs

Objective: To study the effect of different exercise intensity on cardiac function and differential expression of circulating microRNAs (miRNAs) , target genes and gene function in rats with Acute Myocardial Infarction (AMI), Methods: Established AMI models with 40 rats, divided them into 4 groups of sham operation, Isolated Myocardial Infarction, Continuous Moderately Training (CMT), and High-intensity Interval Training (HIT) group respectively, with 10 AMI rats for each group. CMT and HIT rats groups received exercise therapies for 8 weeks. Evaluate cardiac function with echocardiography. Analysed differential expression of circulating miRNAs, related target genes and gene function using miRNAs microarray and bioinformatics technology. Results: CMT and HIT therapies significantly improved cardiac function and exercise tolerance in AMI rats. The effect of HIT group is significantly better than that of CMT group. Compared with sham operation group, 14 circulating miRNAs were obviously up-regulated, 4 circ...