Melissa officinalis Ekstraktlarının Antimikrobiyal Aktivitesinin ve DNA Koruyucu Kapasitesinin Araştırılması

In this study, antimicrobial activity, antioxidant capacity of Melissa officinalis leaf extracts and DNA protective effect aginst H2O2-induced oxidative damage were investigated. DNA protective effect of Melissa officinalis's leaf extract from oxidative stress was determined by using yeast comet assay. The comet assay, applied on Saccharomyces cerevisiae BY4741. We observed that DNA damage decreased in a dose dependent manner in experiments of preincubation and simultaneous incubation with the extract upon oxidative shock. Results indicated that Melissa officinalis's methanolic leaf extract protect the DNA against the damaging effect of hydrogen peroxide. Also we indicated that the antimicrobial effects of Melissa officinalis's extract on the different microorganisms. Extract of Melissa officinalis showed antimicrobial effect on all test test microorganisms.