Propagation of ultrasound-modulated scattered light in biological tissue by using COMSOL multiphysics

Biological tissue is a kind of complex and highly scattering medium. The study of the ultrasound-modulated scattered light propagation in biological tissue is a fundamental problem that must be solved in acousto-optic tomography (AOT). Due to the action of the ultrasonic field, the optical properties of the scattering medium change with time-space, and the propagation of light in it becomes more complicated. In this paper, the finite element simulation software COMSOL Multiphysics is used to simulate the propagation of light in biological tissue under the action of different types of ultrasonic field. The effects of ultrasonic field distribution, ultrasonic intensity and frequency on the light diffusion in the scattered medium are studied. The relationship between the ultrasound-modulated scattering light and the optical properties of biological tissue is discussed. The numerical simulation results are in agreement with the experimental results.