Nonnucleoside reverse transcriptase.

A compound of formula Z: ** (See formula) ** wherein: A is CH or N; R1 is a substituent of a carbon atom in the ring containing A selected from -S (= O) pra, wherein Ra is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, -NHNHC (= O ) ORx, -NRxOH; -C (= O) -Rb, wherein Rb is -C1-C4 alkyl, -ORx, -NRxRx, -NHNRxRx, -NH-C1-C3-C (= O) ORx, -NRxRc, wherein rc is H, C1-C4 alkyl -NRxRx; -C (= O) Rd, -CN, S (= O) pRx, wherein Rd is C1-C4 alkyl, -ORx, -NRxRx -C1-C3 alkyl-O-C1-C3-C (= O ) ORx, -C1-C3-COORx; -C1-C3-ORx - (O-C1-C3) qO-Rx an aromatic 5-membered ring having 1-3 heteroatoms selected from thiazolyl, thiadiazolyl, pyrazolyl, diazolyl and triazolyl; p and q are independently selected from 1 or 2; Rx is independently selected from H, C1-C4 alkyl or acetyl; or a pair of Rx, together with the adjacent N atom may form a pyrrolidine, piperidine, piperazine or morpholine; R2 is a substituent of a carbon atom in the ring containing A and is H, halo, cyano, C1-C4 alkyl, C1-C4 haloalkyl; L is -O-, -S (= O) r- or -CH2-, wherein r is 0, 1 or 2; R3 is H, C1-C3 alkyl; R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6, C1-C6 alkanoyl C1-C6 alkyl, haloalkanoyl C1-C6 alkyl, C1-C6 haloalkoxy, C1-C6 alkyloxy C1-C6 alkyl C1-C6, haloalkyloxy C1-C6 alkyl C1-C6 hydroxyalkyl, C1-C6 alkyl, C1-C6 aminoalkyl, carboxyalkyl C1-C6 cyanoalkyl C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto ; X is - (CR8R8 ') nd- (C88R8' ') m-; T is O or S; D is a bond, -NR 9 -, -O-, -S-, -S (= O) - or -S (= O) 2-; n and m are independently 0, 1 or 2, provided that 0 are not both when D is a bond; R8 and R8 '' are independently H, C1-C3 alkyl, C1-C3 alkyl, hydroxy, or R8 and R8 'together with their adjacent C atom is -C (= O) - R9 is independently H, C1-C3 alkyl; and pharmaceutically acceptable salts thereof; with the proviso that R 1 as -C (= O) Rb is not morfolinoceto-.