Mifepristone versus the Yuzpe regimen (PC4) for emergency contraception

Abstract Objective: To compare side effects, women's acceptance and satisfaction with mifepristone (100 mg) versus the Yuzpe regimen for emergency contraception (EC). Methods: A total of 1000 women requesting EC within 72 h of unprotected intercourse were randomized to receive mifepristone 100 mg or the standard Yuzpe regimen. Outcome measures included patient acceptability and satisfaction. Results: A total of 620 (62%) questionnaires were returned, 64% in the mifepristone group and 60% in the Yuzpe group. Mifepristone was better tolerated than the Yuzpe regimen. The rates of nausea ( P P =0.001), tiredness ( P P =0.001), hot flushes ( P P P Conclusion: Mifepristone has high patient acceptability and few side effects compared to the standard Yuzpe regimen for EC.