4-1BBL/4-1BB costimulation alleviates airway inflammation by restoring Treg/Th17 balance in allergic asthma

Objective : Recent studies have demonstrated Th17/Treg imbalance in patients with asthma and the effect of 4-1BBL/4-1BB on Th17/Treg balance. This study aimed to investigate whether 4-1BBL/4-1BB costimulation alleviated airway inflammation by restoring Treg/Th17 balance in OVA-induced asthmatic mice. Methods : BALB/c mice were randomly assigned to three groups (asthma group, 4-1BB group and control group). Mice in the asthma group were sensitized and challenged with OVA. Agonistic 4-1BB mAb was administered in the 4-1BB group. Mice in control group were treated with PBS. Results : (1) The serum IgE concentration [23.350 (65.945–42.635) ng/L vs. 99.292 (192.185-92.893) ng/L, P 6 vs. (6.44±1.90)×10 6 , P 4 vs. (0.91±0.37)×10 4 , P P P P -3 vs. (30.853 ±5.686)×10 -3 , P Conclusions : Agonistic 4-1BB mAb treatment partially alleviated airway inflammation by restoring the function of Treg cells and inhibiting the proliferation and function of Th17 cells.