A case of multiple primary malignancies following radiotherapy for adenosquamous cell carcinoma of the cervix

Given the extended survival of patients diagnosed with cervical cancer, a large number of women are treated with radiotherapy. A second primary cancer has currently become one of the most important radiation-induced injuries as the number of cancer patients who are cured is increasing by virtue of recent advancements in therapeutic radiology. A 56-year-old woman developed two pelvic malignancies 14 years after undergoing surgery and radiotherapy for adenosquamous cell carcinoma of the cervix. Previous exposure to radiotherapy is associated with certain malignancies, and review of the literature indicates that there is strong evidence to support such an association with bladder and ovarian cancer. This is the first reported case of second multiple primary malignancies (ovarian cancer and bladder cancer) after radiation therapy for adenosquamous cell carcinoma of the cervix.