Pathogenesis of bronchial carcinoma, with special reference to morphogenesis and the influence on the bronchial mucosa of 20-methylcholanthrene and cigarette smoking.

It is generally assumed that squamous cell carcinoma is preceded by a series of progressive epithelial’ changes. The importance of pathogenetic studies is based on the fact that diagnosis and treatment of preinvasive or early invasive lesions can stop the development of epithelial tumors.