Status of the internal organs in nephrotic syndrome

As a result of clinical and experimental observations the authors have established that even at the early stages of the nephrotic syndrome there occur myocardial lesions determined by concomitant impairment of microcirculation and metabolism leading to the development of nephrotic cardiomyopathy. The appearance of the nephrotic syndrome may be accompanied by the development of hydrothorax and more seldom, primarily in acute glomerulonephritis, by nephrogenous edema of the lungs. The nephrotic syndrome does not exert any material effect on the changes in external respiratory function, common to glomerulonephritis. Nephrotic gastropathy is of total character with low magnitudes of acid secretion and intragastric proteolysis. This does not create any conditions for acid-peptic damage to the gastroduodenal mucosa attended by ulcer formation.