RESULTS OF THE STUDY OF THE IMMUNOGENIC ACTIVITY OF CELL ENVELOPES OF FRANCISELLA TULARENSIS DIFFERENT SUBSPICIES (REPORT 2)

The effect of cell envelopes preparations of four subspecies of Francisella tularensis, derived from urea lysates of tula-remia microbe on cytokine production by immunocompetent cells of experimental animals has been studied. Stimu-lating influence of F. tularensis cell envelopes preparations on cytokine synthesis on the 7th day after inoculation was shown. The results showed that the cell envelopes of different subspecies F. tularensis have different stimulatory effect on the production of proinflammatory cytokines and growth factors GM-CSF and G-CSF, further defining the immune system of host .The results allow to consider cell envelopes preparations of F. tularensis as constituent component in the development of subunit vaccines.