Induktion von Harnblasen-Urothelkarzinomen beim Hasen durch Dibutylnitrosamin mit künstlichem Blasenstein als Co-Karzinogen

This study confirm the feasibility of transitional cell carcinomas induction in rabbits by dibutylnitrosamine administered s.c. Additional implantation of an artificial bladder stone acting as a co-carcinogen does not lead to a larger number of tumors, but does seem to enhance the degree of transitional cell carcinomas induction in the bladder