Ignoring Pharmacokinetics May Lead to Isoboles Misinterpretation: Illustration with the Norfloxacin-Theophylline Convulsant Interaction in Rats

Miren Cadart,Sandrine Marchand,Claudine Pariat,Serge Bouquet,William Couet

Ignoring Pharmacokinetics May Lead to Isoboles Misinterpretation: Illustration with the Norfloxacin-Theophylline Convulsant Interaction in Rats

2002

Miren Cadart
Sandrine Marchand
Claudine Pariat
Serge Bouquet
William Couet

Purpose. To investigate the norfloxacin-theophylline convulsant interaction in vivo, with an experimental approach distinguishing between pharmacodynamics and pharmacokinetics contributions to the observed effect.

Keywords:

Drug interaction
Pharmacodynamics
Norfloxacino
Convulsant
Chemistry
Pharmacology
Theophylline
Norfloxacin
Pharmacokinetics
pharmacology toxicology
antibacterial agent

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