Carcinomas detected with PET/CT from asymptomatic individuals

1721 Objectives To investigate potential application of PET/CT to cancer screening. Methods Our institution provides various cancer screening programs including PET/CT. Subjects were asymptomatic screenees who participated in our screening programs. Between May 2005 and December 2007, 2475 individuals participated in 3161 screening sessions (1512 men and 963 women; mean age 54.8±12.2 years). PET/CT was performed in conjunction with other examinations including physical examination, laboratory study (including fecal occult blood test and PSA), US (thyroid, breast, abdomen), MMG, cytology for the uterus, gastrofiberscopy, MRI (brain and pelvis). PET/CT scanning was performed 60 min after injection of 180 to 220 MBq FDG (Discovery ST, GE Healthcare). Follow-up periods were no less than one year. PET/CT results were compared with the screening outcomes. Results By the screening, carcinomas were discovered in 48 of the 2475 participants (1.9%)(Table). PET/CT was true-positive in 28 of the 48 cancers (58%). Most of the PET-positive 28 patients underwent potentially curative surgery. There were 4 carcinomas that could be missed without PET/CT. Conclusions Carcinomas can be detected with PET/CT at a rate of 0.9~1.1% from asymptomatic indivisuals.