Association between metabolic syndrome and intravesical prostatic protrusion in patients with benign prostatic enlargement and lower urinary tract symptoms (MIPS Study)

Objective To investigate the association between metabolic syndrome (MetS) and morphological features of benign prostatic enlargement (BPE), including total prostate volume (TPV), transitional zone volume (TZV) and intra vesical prostatic protrusion (IPP). Patients and Methods From January 2015 to January 2017, 224 consecutive men older than 50 years presenting with lower urinary tract symptoms (LUTS) suggestive of BPE were recruited in this multicentre cross-sectional study. MetS was defined according to international diabetes federation criteria. Multivariate linear and logistic regression models were performed to verify factors associated with IPP, TZV and TPV. Results Patients with MetS showed significantly increase of IPP (p<0.01), TPV (p<0.01) and TZV (p=0.02). At the age-adjusted linear regression analysis, adjusted for age and metabolic factors of MetS, we found that HDL was negatively associated with IPP (r= -0.17), TPV (r= -0.19) and TZV (r= -0.17), while hypertension was positively associated with IPP (r= 0.16), TPV (r= 0.19) and TZV (r= 0.16). At the multivariate logistic regression analysis adjusted for age and factors of MetS, hypertension (categorical) (OR= 2.95), HDL (OR= 0.94) and triglycerides (OR= 1.01) were independent predictors of TPV ≥ 40 cc. We also found that HDL (OR: 0.86), hypertension (OR =2.0) and WC (OR: 1.09) were significantly associated with TZV ≥ 20 cc. At the age-adjusted logistic regression analysis, MetS was significantly associated with IPP ≥ 10 mm (OR= 34.0; p<0.01), TZV ≥ 20 cc (OR= 4.40; p<0.01) and TPV ≥ 40 cc (OR= 5.89; p=0.03). Conclusion MetS shows association with BPE demonstrating relationship with IPP. This article is protected by copyright. All rights reserved.