Recyclable Organocatalyst‐Promoted One‐Pot Asymmetric Synthesis of Spirooxindoles Bearing Multiple Stereogenic Centers.
2016
A recyclable fluorous bifunctional Cinchona alkaloid/thiourea-catalyzed and four-component Michael/Mannich/cyclization sequence has been developed for the asymmetric synthesis of spirooxindoles containing 2-piperidinone and tetrahydropyridine rings. This one-pot reaction process affords the products in good to excellent yields and up to 99% ee and 9:1 dr.
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