Four new metabolites from the endophytic fungus Diaporthe lithocarpus A740

Abstract One new benzophenone derivative, named tenllone I ( 1 ), two new eremophilane derivatives lithocarins B ( 2 ) and C ( 3 ), and a new monoterpentoid lithocarin D ( 4 ), together with two know compounds ( 5 and 6 ) were isolated from the endophytic fungus Diaporthe lithocarpus A740. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation. In addition, all the isolated compounds were evaluated in vitro for their cytotoxic activity. Compounds 2 , 3 , and 5 showed weak inhibitory activities against tumor cell lines.