Influence of the vinyl group on the calcium antagonistic activity of analogues of Fostedil
1994
Abstract Four aryl vinyl diethyl benzylphosphonates related to Fostedil were synthesized and evalued for their in vitro calcium-inhibitory activity. None of these compounds exhibited any calcium antagonistic profile. Unlike a series of diethyl-styryl benzylphosphanates, previously described, the presence of two aromatic rings linked by a vinyl group did not improve the calcium antagonistic activity.
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