Preparation method of 1-(4-chlorophenyl)-2-cyclopropyl-1-acetone and intermediate thereof as well as preparation method of intermediate

2012 
The present invention discloses a 1- (4-Chlorophenyl) -2-cyclopropyl-1-acetone method (I) and the preparation of intermediates and intermediates, in chlorobenzene halo α- acetate (II) and cyclopropyl methyl ketone (III) as starting material, prepared in the presence of a base in the condensation reaction was Darzen glycidic acid ester (IV); glycidic acid ester (IV) is obtained by basic hydrolysis converted to the corresponding salt of glycidol (V), further subjected to decarboxylation under acidic conditions as a fungicide cyproconazole preparation of intermediate 1- (4-chlorophenyl) -2-cyclopropyl-1-propanone (I). The method of the present invention is simple and convenient process, or may be a three-step reaction "pot" is achieved by continuous operation, high content, suitable for large-scale development.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    0
    References
    0
    Citations
    NaN
    KQI
    []