The use of oncolytic viruses in selected tumours

Introduction. Neoplastic diseases are the leading cause of death among adults. Despite significant advances in pharmacotherapy, advanced radiotherapy and high level of oncology surgery, the effects of treatment are still too low. Doctors are attempting to find new, effective methods to cure people suffering from cancer. The big hope for a breakthrough in the treatment of cancer is placed in oncolytic viruses therapy. An innovative approach to viruses, usually associated with a potential risk to health, presents a chance for a breakthrough in oncology. This article is an overview of studies that have used different oncolytic viruses. State of knowledge. Currently, a lot of research is being carried out on the use of viruses in oncology. The mechanism of action of this method is to infect the tumour cells with a virus, replicating inside them and their lysis during the release of new virions. An additional advantage is the possibility for use in many types of cancer and regardless of its clinical stage. Furthermore, virotherapy may be combined with standard methods for achieving greater results. Summary. The results of these studies demonstrate the high effectiveness of this therapy. A large force action is combined with low side-effects and the ability to connect it with other therapies.