Producing an N-acetylgalactosamine-6-sulfatase active highly phosphorylated human and their uses

Compositions of the N-acelilgalactosamina-6-sulfatase (GALNS) human active highly phosphorylated and pharmaceutical compositions and formulations that include methods for the production and purification of GALNS and their use in diagnosis, prophylaxis or treatment of diseases and conditions , which in particular it includes the lysosomal storage diseases that are caused by or are associated with a deficiency in the GALNS enzyme, for example, mucopolysaccharidosis IVa (MPS IVa or Morquio a syndrome).