Fluorescent probes for detecting glutathione: Bio-imaging and two reaction mechanisms

2019 
Abstract A series of compounds ( W1 - W8 ) based on triphenylamine with -C=N- or -NH- group, were designed and studied by fluorescence emission spectra and DFT/TDDFT calculations. Probes W1 - W4 were selectively leveraged to sensitively detect glutathione by two distinct reaction mechanisms, thereinto, W1 - W2 featured a convenient detection for glutathione using hydrolysis and W3 - W4 utilized displacement to probe glutathione possessing sensitivity and practicability. Compound W5 - W8 here provided an avenue for understanding structure-property relationship. Taken considerations for toxicity and biocompatibility together, W1 - W4 showed great advance for endogenously and exogenously imaging GSH in living cells.
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