儿童嗜酸性粒细胞增多性心内膜心肌病伴脑梗塞1例报告 One Case Report of Hypereosinophilic Carditis Combined Cerebral Infarction in Child

特发性嗜酸性粒细胞增多综合征是临床少见疾病，最常见于热带成年男性病人，主要累及皮肤、心脏、中枢神经系统等脏器，儿童少见。累及心脏可引起嗜酸性粒细胞增多性心内膜心肌病，累及中枢神经系统可引起神经行为改变及脑梗塞等。本例患儿为7岁男孩，入院时症状为流涕、喷嚏20天，发热2周，头痛、腹痛3天。入院后查血片嗜酸性粒细胞占80%，超声心动图显示考虑嗜酸细胞增多综合征(loffler心内膜炎)。颅脑MRI：双侧大脑半球多发异常信号，考虑多发微小缺血梗死灶或炎性改变。给予口服泼尼松治疗4周后好转。该病治疗目前无特殊方法，主要依靠糖皮质激素和其他免疫抑制剂。 Idiopathic hypereosinophilic syndrome is minority in clinical. And more cases were found in male adults while only less cases were found in children. This disease could destroy skin, heart and central never system etc. When the heart was destroyed, it could be named hypereosinophilic carditis. And it also could distroy brain and caused cerebral infarction. As following case, we reported a case of hypereosinophilic carditis combined cerebral infarction in child. The case was a 7 years old boy. Its clinical symptoms were shed tears and sneezing for 20 days, fever for 2 weeks, headache and abdominal pain for 3 days. Eosinophilic cells were 80% of all WBC. Heart echo displaied loffler carditis. Head MRI displaied cerebral infarction. After oral prednison for 4 weeks, the boy came through. This disease had no very effective treatment up to now. The sugar cortical hormone and other immunosuppressant might be effective drugs.