Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

Takahisa Kanekiyo,Juan Zhang,Qiang Liu,Chia Chen Liu,Lijuan Zhang,Guojun D Bu

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

2011

Takahisa Kanekiyo
Juan Zhang
Qiang Liu
Chia Chen Liu
Lijuan Zhang
Guojun D Bu

National Institutes of Health [R01AG027924, P01AG030128]; Alzheimer's Association; American Health Assistance Foundation; American Heart Association; National Institutes of Health Neuroscience Blueprint Center Core [P30NS057105]

Keywords:

Proteoglycan
Transfection
Endocytosis
Blood–brain barrier
LDL receptor
Apolipoprotein E
Biochemistry
Downregulation and upregulation
Amyloid
Biology
amyloid β
heparan sulphate proteoglycan

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