α-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKα in vitro

The energy-sensing kinase AMPK is regulated by phosphorylation, however, the identity of AMPK phosphatases remains uncertain. Here the authors show that α-SNAP, a protein previously known for its role in membrane fusion, can dephosphorylate AMPK despite lacking a recognizable phosphatase domain.