Optimization of high-flux, hollow-fiber artificial kidneys
2004
Over the past few decades, attempts to improve artificial kidneys have largely been a quest to optimize solute removal or clearance during therapy by altering membrane permeability. This emphasis on membrane permeability was propelled largely by the middle molecule hypothesis and a desire to obtain solute removal characteristics for artificial kidneys similar to those of the native organ. As of a decade ago these achievements were approximately realized.
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