METABOLIC ASPECTS OF THE EFFECT OF NERVE GROWTH FACTOR ON SYMPATHETIC AND SENSORY GANGLIA: PROTEIN AND RIBONUCLEIC ACID SYNTHESIS.

Abstract Evidence is presented that the nerve growth factor markedly stimulates the rate of amino acid incorporation and turnover in sensory and sympathetic ganglia in vitro . Under these conditions the nerve growth factor calls forth an even higher increase in RNA synthesis as proved by labeled uridine experiments. Inhibitor experiments with puromycin and actinomycin D suggest that the nerve growth factor stimulation of protein synthesis is dependent on a primary effect on nuclear RNA synthesis.