Alkylnaphthalenes. I. Absorption, tissue distribution and excretion of 2,6-diisopropylnaphthalene in rats.

Upon a single oral administration of 2, 6-DIPN (100mg/kg) to rats, about 85% of the dose was absorbed from the gastrointestinal tract during 48 hr after the administration. Only a small amount of unchanged 2, 6-DIPN was excreted in urine. The maximum levels of 2, 6-DIPN in the liver, kidney, heart, spleen, brain and muscle were obtained within 4 hr after the administration and then the levels decreased with time. However, the time for reaching the maximum level of 2, 6-DIPN in the skin and adipose tissue was longer than that in the other tissues. In addition, the content and disappearance of 2, 6-DIPN in the adipose tissue were higher and slower than those in the other tissues.