ID 283 – EEG markers of motor activity in physiological aging and Alzheimer’s disease mouse models

Objectives In the framework of IMI PharmaCog project (Grant Agreement n°115009), we evaluated whether spectral electroencephalographic (EEG) markers of motor activity change across aging in wild type (WT) mice and in transgenic models of AD. Methods All animal studies were carried out ethically (86/609/EEC). EEG data were recorded from bipolar fronto-parietal electrode in 85 WT mice, 22 PDAPP, and 33 TASTPM mice. Artifact-free EEG segments during wake active and passive state (no sleep) were used as input for EEG power density analysis. Results Statistical results ( p Conclusions EEG markers of motor activity are useful to unveil neurophysiological mechanisms of cortical neural synchronization characterizing the physiological and pathological aging in mice.