An Infection Model for COVID-19

We wish to propose an infection model to address some of the unique and unusual features observed in coronavirus disease 2019 (COVID-19), e.g., why were severe patients mounting more intense immune response compared to the mild cases, and why did severe patients demonstrate higher and more protracted viral shedding when their immune responses were more intense. In this exposition, we will first construct a pathogenic model for COVID-19, and followed with a discussion on how it may influence critical aspects of COVID-19 management. By extrapolating from this model, we will highlight important and potential therapeutic strategies. This proposed model is intended to provide a generalized framework, but it requires validation from further clinical studies.