Detection method for sildenafil citrate related substances

The invention discloses a detection method for sildenafil citrate related substances. The high performance liquid chromatography is adopted in the detection method, octadecylsilane bonded silica gel is used as a chromatographic column for the stationary phase, an ammonium acetate water solution is used as the mobile phase A, an acetonitrile-methyl alcohol mixture is used as the mobile phase B, the detection wavelength is 292 nm, and gradient elution is carried out. The detection method is simple, efficient, high in resolution and capable of separating and detecting seven related substances in sildenafil citrate at the same time, and the mobile phases are suitable for mass spectrometric detection and can be used for quality research and quality control over sildenafil citrate raw material drugs and preparation products.