The 5-Year Outcome for Patients Diagnosed With Locally Advanced Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemotherapy and Proton Beam Therapy

functional lung. The median NTCP for RP in the perfused lung was 8.9% compared with 7.0% for the original and adapted plans respectively (p < 0.01). The median NTCP for RP in the ‘well perfused’ lung was 8.4% compared with 6.6% for the original and adapted plans respectively (p < 0.01). Conclusions: Plans adapted to functional lung allowed for significant technical improvement of IMRT for NSCLC patients, with a larger magnitude of improvement noted in plans optimized for ‘well perfused’ rather than ‘perfused’ lung. This study demonstrates proof-of-principle that 4D 68Ga-perfusion PET/CT can be used to spare dose to functional lung using IMRT planning techniques. Author Disclosure: S. Siva: None. T. Devereux: None. N. Hardcastle: None. J. Callahan: None. D. Pham: None. P. Eu: None. D. Steinfort: None. M. Bressel: None. M. MacManus: None. T. Kron: None. R. Hicks: None. D. Ball: None. M. Hofman: None.