Effect of Methadone on Cardiac Conduction in Young Patients with Cancer-Related Pain: A Retrospective Study

While current literature suggests that methadone for analgesia, alone or in conjunction with other risk factors, may affect cardiac conduction - producing EKG changes ranging from mild QTc prolongation to torsades de pointes and ventricular fibrillation, there is minimal data on the effects of methadone on QTc interval in the pediatric population. A retrospective review of automatic and manual QTc measurements from patients on methadone therapy for analgesia in conjunction with dosage …