Enantioselective synthesis of S-1452, an orally active potent thromboxane A2 receptor antagonist

An efficient and extremely practical enantioselective fission of pro-chiral bicyclo[2.2.1]heptane-2,3-dicarboxylic anhydride was applied to the asymmetric synthesis of the potent and orally active thromboxane A 2 (TXA 2 ) receptor antagonist, S-1452