Anti-inflammation mechanism of ibuprofen tetramethylpyrazine ester

Objective To elucidate the anti-inflammation mechanism of ibuprofen tetramethylpyrazine ester(ITE).Methods The model of paw edema induced by carrageenin was used to determine the effect of ITE on the content of prostaglandin E_2(PGE_2) and malondialdehyde(MDA) in the exudates.The activities of superoxide dismutase (SOD) in serum and catalase (CAT) in red blood cell were observed.The weight of adrenal and the content of vitamin C were also measured.Results It was found that the contents of MDA and PGE_2 in the exudates in the groups treated by ITE were much lower than those in the control group.In addition,the activities of SOD in serum and CAT in red blood cell were enhanced by ITE.The suppressive effect on ear edema in mice without adrenal was observed and ITE had no obvious effect on either the weight of adrenal or the content of vitamin C.Conclusions These results suggest that the mechanism involved in the anti-inflammation of ITE is partly due to the influence on cyclooxygenase(COX) and the synthesis or release of free radical,but not relate to pituitary-adrenal system.