Response of Lymphocite in Model Animal Suppelemented withLactic Acid Bacteria from Dangke by Protection Test ofEscherichia Coli

Lactic Acid Bacteria is a gram-positive bacteria that can produce lactic acid that has potential as a probiotic. The mechanism of action is by the production of antimicrobial substances, nutritional competition and space adhesion, and immune stimulation. The objective of this study was to investigate the response of lymphocytes of mice (Mus musculus) with Lactic Acid Bacteria supplementation from dangke Enterococcus faecium and Lactobacillus plantarum which were challenged with EPEC (Enteropathogenic Escherichia coli). The method used was supplementation using lactic acid bacteria orally with 6 treatement ie group A (negative control, without treatment), group B (Enterococcus faecium), group C (Enterococcus faecium + EPEC), group D (Lactobacillus. plantarum), group E (L. plantarum + EPEC), and group F (positive control, EPEC administration). Lactic Acid Bacteria Enterococcus faecium and Lactobacillus plantarum isolated from dangke have the ability to increase the immune system of mice caused by EPEC (Enteropathogenic Escherichia coli).