Bioanalysis of therapeutic monoclonal antibody by peptide adsorption-controlled LC–MS

Noritaka Hashii,Yoshiko Tousaka,Koji Arai,Yoshimasa Enoki,Suguru Fukuda,Ryoya Goda,Noriko Inoue,Mitsuhiko Kawabata,Kazuyuki Murata,Mio Nakatsuji,Takeshi Okuzono,Takuma Shigeyama,Hidehisa Tachiki,Takeru Yamaguchi,Shinichi Yamane,Mariko Yamaoka,Yoshiro Saito,Akiko Ishii-Watabe

Bioanalysis of therapeutic monoclonal antibody by peptide adsorption-controlled LC–MS

2021

Noritaka Hashii
Yoshiko Tousaka
Koji Arai
Yoshimasa Enoki
Suguru Fukuda
Ryoya Goda
Noriko Inoue
Mitsuhiko Kawabata
Kazuyuki Murata
Mio Nakatsuji
Takeshi Okuzono
Takuma Shigeyama
Hidehisa Tachiki
Takeru Yamaguchi
Shinichi Yamane
Mariko Yamaoka
Yoshiro Saito
Akiko Ishii-Watabe

Aim: We aimed to develop an easy, low-cost and versatile mass spectrometric method for the bioanalysis of a therapeutic monoclonal antibody (mAb) in human serum that employs peptide adsorption-cont...

Keywords:

Liquid chromatography–mass spectrometry
Selected reaction monitoring
Chemistry
Peptide
Chromatography
mass spectrometric
Adsorption
Bioanalysis
Monoclonal antibody

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