Fluorination of (+)-chiro-Inositol with SF4/HF to Give 2α,3β-Difluoro-7-oxabicyclo [2.2.1]heptane-5α,6α-sulfite.
2002
Abstract The fluorination of (+)- chiro -inositol with SF 4 /HF under moderate conditions affords a single product studied by 1 H and 19 F and 13 C NMR spectroscopy. These have been fully assigned with the aid of other physical techniques and compared with a computer-generated model. This data indicate the product to be 2α,3β-difluoro-7-oxabicyclo[2.2.1]heptane-5α,6α-sulfite 3 which was subsequently confirmed by single-crystal X-ray analysis. A mechanism for the reaction is proposed and is compared with that proposed for the formation of the product obtained from the fluorination of myo -inositol.
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