Clinical Features, Diagnosis and Treatment of Children's Wernicke’s Encephalopathy

To explore the clinical features, diagnosis, and treatment of Wernicke’s encephalopathy (WE) in children and raise awareness of the disease. Summarize the clinical manifestations, diagnosis, and treatment characteristics of a WE case in a child patient with severe sepsis as the first manifestation and review the literatures of children cases reported at home and abroad in recent years. Children's WE often have no specific clinical manifestations, so the misdiagnosis rate is high. The MRI features of the brain show signs of symmetric abnormalities in bilateral mammillary body, basal ganglia, and cerebral periaqueductal area, etc. The characteristic brain MRI abnormal signal combined with rapid response after clinical thiamine treatment is helpful for clinical diagnosis. Early and timely supplementation of large doses of thiamine resulted in rapid improvement of neurological abnormalities in most cases with good prognosis.