C-type lectin receptors orchestrate antifungal immunity

Immunity to pathogens critically requires pattern recognition receptors (PRR) to trigger intracellular signaling cascades that initiate and direct innate and adaptive immune responses. For fungal infections, these responses are primarily mediated by members of the C-type lectin receptor family. In this review, we highlight recent advances in our understanding of the roles and mechanisms of these multifunctional receptors, explore how these PRR orchestrate anti-fungal immunity, and briefly discuss progress in the use of these receptors as targets for anti-fungal and other vaccines.