Studies on the determination of the human glycine pool

Abstract 1. 1. Studies on the human glycine pool were carried out by means of hippuric acid synthesis using 15 N-labeled glycine. The size of the human glycine pool was calculated from the content of 15 N in urinary hippuric acid. 2. 2. The normal range was found to be 34.3 to 48.1 mg N/kg body weight; these values were discussed. 3. 3. The size of the glycine pool of patients with various liver diseases was compared with the normal values. In acute liver diseases, the size of the glycine pool was generally larger. On the other hand the size of the glycine pool was found to be smaller in chronic cases.